연세대학교 이과대학 화학과

일시 : 2024년 3월 28일 오후 5시

장소 : 과학관 B133호

초록 : Ribosomes are molecular machines that have evolved to polymerize L-alpha amino acids into peptides or proteins with amide linkages. Here, I discuss our recent investigation into leveraging the ribosome’s polymerization ability to produce a novel chemical motif, pyridazinone, on a cell-free platform instead of via a peptide bond. Specifically, I explain a ribosome-catalyzed cyclocondensation reaction between activated γ-keto and α-hydrazino ester monomers. This reaction demonstrates the ribosome’s catalytic mechanism is plastic, as observed in both remnants of evolution and current efforts to expand genetic codes. Based on this result, we anticipate that rational designs of non-canonical monomers and engineering of the translational machinery in the system may open new opportunities for developing genetically encoded chemistry, transforming drug discovery practices beyond traditional boundaries.